Studies on the Transition Metal Complexes of Schiff Bases with Heterocyclic Amines

Abstract

With an aim to prepare some model complexes, six ligands were prepared. They are arranged in three series depending on nature of the ligands and their donating capability. A variety of aldehydes and a verity of primary amines were used to prepare different Schiff base ligands. The thesis also extended to synthesis and characterization of some transition metal complexes containing Schiff base as primary ligands and hetero-cyclic amines as secondary ligands. The complexes were isolated in solid form and characterized on the basis or elemental analysis, conductivity, magnetic measurements, UV, IR and NMR spectral analysis and crystallographic analysis also. The Schiff base complexes were screened for biological activities such as antibacterial, anti fungal, cytotoxicity and antioxidant properties. For description, we have divided the whole thesis into three sections viz. section A, B, & C. SECTION-A This section contains two chapters (chapter I-Il) ClfAPTER-1 This is an introductory chapter. This chapter is designed to provide sufficient background and usefulness of the present study. CHAPTER-II This chapter describes the experimental techniques, which include the chemicals, physical measurements, and analytical techniques. SECTTON-B This chapter contains four chapters (chapter III-VJ) Dharmaraj an et. al. 109 have reported the synthesis and evaluation of various diclofenac acid hydra zones and amides for invitro and in vivo antimicrobial activities against Micro Bacterium tuberculosis. Schiff base Tetrazamacrocyclic ligand and its complexes of the types, [MLX2] and [CuL]X2 [M= Co (II), Ni (II), Zn (II); X= er, N03-/ synthesized and characterized by elemental analyses, mass, H-N MR, IR, U V-Viss, magnetic susceptibility and molar conductance data. The complexes shown antimicrobial activity against various pathogens. 110-111 Lei et. al. 112-113 have reported the synthesis of a series of Schiff bases (Fig. 4) by reacting 5-Chlorosalicyldehyde and primary amines. The compounds were assayed for antibacterial and anti fungal activities. It is also reported that salicylaldehyde derivatives, with one or more halo-atoms in the aromatic ring, showed variety of biological activities.